Senior Scientist - Computational Biology

Job Description

Job Description

New hires in Non-Field based roles in the U.S. & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, non-office based roles who routinely collaborate with external stakeholders such as employees in customer facing commercial or research based roles will be required, subject to applicable law, to be fully vaccinated as a condition of employment.

We are seeking an innovative, highly motivated Computational Biologist to join our team dedicated to advance our Cardiometabolic Disease (CMD) portfolio.

As a Senior Scientist in CMD, you will:

• Be part of creative and enthusiastic teams working on target identification and validation (TIDVAL) for heart failure, NASH, retinal diseases, and vascular disease
• Work with dynamic cross-functional matrixed teams to support discovery activities and CMD portfolio
• Be responsible for growing internal capabilities by adapting pipelines and creating new data analysis solutions to analyze large scale omics data (transcriptomics, genomic, genetic, metabolomic, proteomic) for TIDVAL
• Develop novel machine learning approaches to learn target biology and identify disease mechanisms from multimodal phenotypic data and -omics based datasets
• Work with in-house, open-source and/or commercially available platforms for the processing and analyzing large datasets
• Engage and collaborate with wet lab scientists on experimental design, data analysis and interpretation, and mechanistic understanding of target biology
• Identify, integrate and analyze internal and external datasets to guide target validation and gain mechanistic insights into disease biology
• Collaborate with academic and external partners aimed at gaining valuable insights from innovative data science technology and pioneering analytic approaches
• Have a proven track record across a wide range of computational biological methods, including but not limited to: next generation sequence data analysis, especially bulk RNAseq and scRNAseq, mathematical modeling, machine learning, and data mining
• Collaborative mindset with strong communication and presentation skills

Education Minimum Requirements

• Ph.D. in Bioinformatics, Computational Biology, Computer Science, Genetics, Physics, or related field, experiences with machine learning and modeling is a plus

Required Experience and Skills

• Hands on experience in performing analysis and interpreting biology with large-scale omics datasets including genetics, transcriptomics, single cell RNA-Seq, proteomics, metabolomics is required
• Advanced skills in algorithm design and modeling using machine learning, exploratory data analysis, statistical modeling and techniques is required
• Understanding the pros and cons of various algorithms for DNA-seq, RNA-seq and single-cell RNA-seq analysis is required
• Proficiency in at least one programming language, such as R, Python, Perl or MatLab
• Highly motivated, capable of prioritizing projects and providing high quality deliverables on time
• Demonstrated ability to provide technical support, perform translational research, and contribute to cross-functional projects
• Effective written and verbal communication skills

Preferred Experience and Skills

• Capability of integrating multiple resources to strengthen research comprehensiveness
• Experience in applying computational methods to problems in cardiovascular and metabolic disease
• Familiarity with public databases and repositories of DNA and RNA profiling data
• Strong publication record

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are ...

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for ...

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R165921