In Vivo Senior Scientist- Oncology

Job Description

Job Description:

As an In Vivo Senior Scientist, you will support AstraZeneca’s industry-leading drug portfolio within the Oncology In Vivo Biosciences Team! At our state of the art Biohub facility in Waltham MA, we will offer you opportunity to work with a team of cross functional scientists and be responsible for the in vivo pharmacology strategy supporting deliverables for early and late stage projects. This is essentially critical to supporting the development of new and successful cancer therapies!

Key Responsibilities:

• Design and deliver in vivo screening cascades to support lead optimization and candidate selection for new drug target programs.
• Deliver comprehensive in vivo pharmacology data packages for drug candidates in early clinical development, including PK/PD and efficacy studies, dose and schedule optimization, and in vivo combination studies.
• Work collaboratively with translational scientists to support patient selection strategies and identify biomarker response signatures.
• Bring in new technologies and approaches to explore efficacy of epigenetic therapies/ combinations (longer duration).
• Work collaboratively with colleagues to develop and implement bold work plans and timelines.
• Mentor/supervise/train more junior lab scientists

Minimum Requirements:

• BS or MS in Pharmacology or related subject area, with a minimum of 2 years relevant experience, including experience in Biopharma.
• Experience delivering all aspects of in vivo pharmacology studies in mouse tumor models
• Skilled in dose-finding tolerability studies, PK/PD studies, and efficacy studies.
• A solid understanding in expanding/banking patient derived xenograft models is preferred
• Experience developing and working with complex in vivo models of cancer, such as disseminated/subcutaneous xenografts, patient-derived xenograft models and humanized models of cancer.
• Strong track record of working across boundaries to deliver common goals.
• Ability to lead from the bench in problem solving and in the development of innovative solutions.
• Excellent communication and presentation skills
• A proven track record of high productivity and scientific publications in peer reviewed journals.

Waltham, MA:

Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park BioHub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world’s most vibrant research centers.

Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be an excellent fit, please share this posting with them.

As part of the application process for some roles at AstraZeneca, candidates may be asked to complete a series of online games, created by pymetrics, to assess certain candidate qualities to help evaluate potential match for the position. If the pymetrics process applies to this role, you will receive an email invitation with additional information following application. Once completed AZ will automatically receive your results - pymetrics will not be used solely in our decision-making process but will help us gather additional insight