Senior Scientist II, Modeling & Informatics - Chemistry & Structural Chemistry

Job Description

Job Description

Our company's Research Laboratories South San Francisco, a wholly-owned subsidiary, is focused on driving discovery research. Our new multi-disciplinary discovery research site offers state-of-the-art resources to explore the most promising science combined with our comapny's world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay Area’s biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of our company's powerful world-class network of drug and vaccine discovery.

At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our company's Research Labs South San Francisco, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

Our company is currently seeking a highly motivated and exceptional scientist with a focus on biologics, peptide, and bioconjugate modeling in the Modeling & Informatics group within the Computational and Structural Chemistry department at our South San Francisco site. The successful candidate will join multidisciplinary, highly collaborative discovery teams both locally and across the global company network to invent novel medicines by leveraging medicinal chemistry experience, applying advanced computational techniques, and developing innovative computational methods.

Required Education:

• Ph.D. in biophysics, biochemistry, chemistry, engineering, or equivalent

Required Experience:

• 2+ years of small molecule drug discovery experience in a biopharma setting
• Experience with use of modeling in the optimization of small molecules for improved potency, pharmacokinetics, and drug metabolism
• Experience with at least one of the following modeling software packages: MOE, Schrodinger, OpenEye
• Experience with Linux and Python scripting
• Strong written and oral communication skills, and demonstrated ability to work well in multidisciplinary teams
• Multiple publications and/or external presentations demonstrating creative application of computational approaches to problems of biological interest

Preferred Experience:

• Experience with quantum chemistry calculation software such as Gaussian
• Experience with use of machine learning for modeling small molecule SAR
• Experience applying computational methods such as docking, conformational analysis, and homology modeling to problems of biological interest

Key Responsibilities:

• Collaborating with interdisciplinary discovery teams to invent new small molecule, peptide, and bioconjugate medicines
• Applying a variety of informatics and modeling techniques to accelerate the evolution of drug discovery leads to drug candidates
• Continuing research in areas of molecular modeling relevant to drug discovery, and maintaining an external scientific presence through high-impact publications and presentations

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are ...

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for ...

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

Invent. Impact. Inspire.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Relocation:

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Flexible Work Arrangements:

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Requisition ID:R109245