Postdoctoral Research Scientist-Antibody Discovery & Engineering-FDE

Job Description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Lilly is excited to offer this chance to join our postdoctoral community and engage in groundbreaking research. We are looking for a hardworking applicant experienced in protein/antibody engineering research. This role is on our Discovery & Engineering Team responsible for the development of therapeutic antibodies against diverse therapeutic targets. The focus will be on antibody engineering technologies, in combination with structural biology, to develop engineering concepts to introduce or improve pH dependent binding properties and strategies to discover pH dependent antibodies de novo. A main objective will be building and testing library-based approaches, screening methods and structural modeling to enable semi-rational or rational mutagenesis. Does this sound intriguing? Apply today and continue your learning journey in an industry setting!

Area of Research

• Probing the Mechanism of Action and binding limitations of a known pH-dependent Ab/Ag System. Study, in structural detail, the fundamental MoA of an established pH-sensitive antibody switch system to ultimately drive protocols and improve p(TS) for generating such systems at Lilly.
• Development and testing of strategies to discover de novo and/or engineer antibodies with introduced or improved pH dependent binding properties (including screening, semi-random mutagenesis/library design).
• Implementation of structural modeling and in silico design strategies to enable rational mutagenesis. If possible, development of a platform solution to discovery of pH dependent antibodies.

Basic Qualifications:

Ph.D. degree in molecular biology, biochemistry or related field, preferably with emphasis on protein/antibody engineering

Additional Skills and Preferences:

• Knowledge and hands-on experience in protein/antibody library design, construction, screening and protein chemistry
• Good understanding of antibody structure and function
• Experience with phage display and/or other molecular evolution technologies a plus
• Experience in structural modeling and design
• Ability to write scientific reports and publications
• Ability to work in a creative, fast-paced and productive team environment
• Great teammate with strong interpersonal skills
• Good time management and organizational skills

This position is not permanent. It is for a fixed duration of two years and possibility of extending to maximum of up to 4 years.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( [email protected] ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide valid proof of vaccination to the company.