Scientist, Oncology Bioscience

Job Description

Scientist, Oncology Bioscience

Would you like to apply your expertise to impact drug development in a company that follows the science and turns ideas into life-changing medicines? Then employment at AstraZeneca might be the right choice for you!

We are seeking a highly motivated Scientist in Oncology Targeted Discovery with strong scientific and technical expertise in oncology research with a track record of scientific excellence to join our team in Waltham, MA USA. As a Scientist in our Oncology R&D department, the scientist will be a key member of a team focused on supporting oncology projects through the drug discovery and development process. You will bring your theoretical and practical expertise in cancer biology to establish assay systems and deliver datasets that will have a direct impact on targeted therapeutics.

Accountabilities

The scientist will work in a laboratory within the Oncology Research group designing, conducting, and analyzing in vitro experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel therapeutics. You will also review emerging literature and internal data to identify new targets and contribute to target validation activities.

Essential Skills/Experience

• BS with 3+ years or MS with 1+ year experience in Biology, Oncology, Biochemistry, Pharmacology, Immunology or a related field
• Depth of understanding of solid tumor and hematological cancer models
• Experience with a range of in vitro skills for the analysis of human tumor cell function (e.g. cell culture, cell signaling bioassays, Western blot, and cell death measurement in primary and cell line cultures)
• Experience conducting flow cytometry and visualizing/quantitating high content multi-parameter flow data
• Able to drive multiple projects in parallel to enable go/no-go decisions pertaining to program landmarks and portfolio advancement
• Experience with multiple in-vitro tumor models (2D, 3D, organoid etc)
• Experience with genetic tools for cell line engineering (si/shRNA, CRISPR, transfection, transduction)
• Experience with imaging/microscopy (fluorescence microscopy, immunofluorescence, confocal and/or high-content)
• Experience with cell biology and biochemical techniques to characterize cell signaling pathways (e.g. immunoprecipitation, immunofluorescence, luciferase activity, MSD/Luminex, qPCR)
• Molecular biology skills including assessment of intracellular signaling and generating and/or analyzing transcriptomic and proteomic data
• Works equally well independently and in collaboration to complete assigned tasks in a manner consistent with project goals. Reports data in a clear and concise manner, with a comprehensive understanding of its implications within the overall context of drug discovery.
• Strong interpersonal and collaboration skills together with evidence of having used these to support problem-solving and delivery in a collaborative environment.
• Good organizational skills and able to design/execute experiments with a significant degree of independence

Desirable Skills/Experience

• Prior experience in the biopharmaceutical industry preferable but not required.
• Familiarity with antibody drug conjugates or other targeted delivery modalities
• Familiarity with multiple drug modalities preferable but not required
• Familiarity with biology of tumor microenvironment (TME)
• Knowledge of the drug discovery process and publications in credible scientific journals

At AstraZeneca, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. Empowered by the business and each other, we embody courage and curiosity, taking smart risks, challenging the norm, and learning from failures. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. It's science with an impact—making a difference for patients and people around the world.

Ready to make a meaningful impact? Apply now!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.