Senior Scientist – Biomolecular Interactions

Job Description

Senior Scientist – Biomolecular Interactions

Join AstraZeneca's Biologics Engineering (BE) team, where we turn ideas into life-changing medicines. We are looking for a highly experienced and motivated senior scientist for our Biomolecular Interactions Group (BMIG) within the multidisciplinary Protein Analytics & Developability team. As a Senior Scientist in the Biomolecular Interactions Group, you will be instrumental in advancing our capabilities in high throughput kinetic characterization of antibody-antigen interactions. Reporting to the Associate Director of the Biomolecular Interactions group, the successful candidate will work closely with a multidisciplinary team to support various stages of our pipeline projects and contribute to the enhancement of our technology platforms.

Accountabilities

• Design and execute high-throughput (HT) assays for biomolecular interactions, focusing on kinetic characterization and epitope binning of antibody-antigen interactions using biosensor-based techniques, particularly Surface Plasmon Resonance (SPR) with platforms such as Carterra LSA.
• Perform and optimize binding kinetics, affinity measurements, and other relevant assays to support large molecule drug discovery projects.
• Collaborate with the Protein Analytics and Developability team to refine HT assay workflows, ensuring accuracy and reliability in data collection and interpretation.
• Analyze and interpret complex datasets, providing insights to drive decision making in pipeline projects.
• Stay at the forefront of technological advancements in biosensor and other biophysical technologies and integrate innovative solutions to enhance current workflows.
• Participate in cross-functional project teams, contributing technical expertise to inform project strategies and directions.
• Draft technical reports and contribute to scientific publications, patents, and regulatory submissions as necessary.
• Mentor junior scientists in experimental design and data analysis to foster a collaborative and productive research environment.

Essential Skills/Experience

• Bachelors degree with 7+ years of relevant experience or MS with 4+ years of relevant hands-on experience.
• Proven expertise in conducting high-throughput biomolecular interaction assays, particularly with antibodies and antigens, using biosensor-based platforms like Carterra LSA and Biacore.
• Experience in assay troubleshooting and optimization, with a strong understanding of assay development and execution.
• Proficiency in data analysis and statistical methods for interpreting complex biological data.
• Hands-on experience with other protein analytical and biophysical techniques and instrumentation is advantageous.
• Strong collaborative skills and ability to work effectively within multidisciplinary teams.
• Excellent communication and presentation skills to convey technical information clearly and succinctly.

Desirable Skills/Experience

• PhD in Biochemistry, Chemistry, Bio/Chemical Engineering, or a related field

At AstraZeneca, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. Our interdisciplinary approach includes novel biomarkers, AI, novel endpoints, and ground breaking trial designs. By constantly innovating, we develop life-changing medicines that improve outcomes for patients everywhere. Our supportive team players draw on diverse knowledge from across the business and external partners to tackle the toughest medical challenges. Empowered by the business and each other, we embody courage and curiosity, taking smart risks, challenging the norm, and learning from failures.

Ready to make a difference? Apply now to join our team!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.